You can take the Alilaguna Water Service, Orange Line, directly from the airport to the Madonna dell’Orte ferry terminal. From there it’s just a 5-minute walk to the hotel. Another option is to take the bus or a taxi from the airport to Piazzale Roma and from there take the Vaporetto, Line 4.1 or 5.1 to the same terminal.
The Alilaguna service is 27 euro for a roundtrip ticket, 25 if purchased in advance. You can get a combination bus/Vaporetto ticket for 14 euro for a one-way trip to or from the airport. There are also multi-day tickets that include the trip to and from the airport that might be worthwhile if you think you might use the Vaporetto while in Venice. The typical taxi fare from the airport is 40 euro plus luggage fees and tip, but it’s the quickest way to get to Piazzale Roma.
You have a few options. If the weather is nice the ride across the lagoon using the Alilaguna service can be nice and it avoids the transfer from bus/taxi to Vaporetto. Either method will likely take at least an hour plus waiting time for the next boat to bus.