If the weather is nice upon your arrival consider using the Alilaguna Water Bus. You can take either the red, blue or gold line as they all stop at San Zaccaria, which is where you want to get off. Your hotel is a short walk from the water bus terminal.
The other option would be to take the ATVO bus or a taxi from the airport to Piazzale Roma and then hop on the Vaporetto, line 1 or 2 and get off at San Zaccario.
The cost is close between the two options. If the weather is nice I would opt for the Alilaguna as it eliminates the transfer from bus/taxi to the Vaporetto. Also, the ride across the lagoon will give you a nice view as you approach Venice.